He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. Proven in clinical use all over the world. We didnt come up with better mouse technology than Microsoft did. This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. Comparison with molnupiravir. Read More fluvoxamine The Fluvoxamine FAQ And not zero., Kirsch immediately forwarded the exchange to me and, I suspect, other journalists. When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. Elsewhere he has said he began questioning vaccine safety after an unnamed Twitter follower told him several family members died after getting their shots. That was a big mistake because the original paper contained text related to earlier studies and the editors chopped it out. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? We should not wait for the Phase 3 RCT. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. That covers almost 150,000 of them, which happened before vaccinations began. Part of TV News Archive. I couldnt tell I was on the drug. You cannot get any better than that. Im taking low dosage Fluvoxamine as part of a multi-drug FLCCC protocol to alleviate some mild brain fog. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. People who report not tolerating the drug are typically prescribed too high a dose. It used to be that a Phase 3 study would do it. That receptor also helps regulate the body's . Worst case, if we ignore all additional evidence so the average is a 60% pass rate. fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? We should be making decisions now based on the evidence on the table today. The medical community doesnt care about saving lives. Thats why they didnt even fund the fluvoxamine trial, he told me. Its motivated out of his sense of keeping people safe and advancing health care.. . And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? The medical community doesnt care about saving lives. If you continue to get this message, The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. It is perhaps the greatest unnecessary loss of life in American history. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. JAMA systematic review and meta analysis It doesnt get any better than this. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. I will . Instead, it erodes confidence in our government to provide timely advice that is in the public interest. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. Doctors have no excuse for not prescribing. One Silicon Valley entrepreneur thought he could beat the odds. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). The babys brain was split in half, and it was just covered with blood. I see it all the time on social media, Morris told me. Steve Kirsch is an inventor of the optimal mouse, a Silicon Valley millionaire, and an MIT alum (Class of '80). But not 150K. Note that some of these articles are inaccurate. ). . We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. Try refreshing this page and updating them one Once the Phase 2 result came out, it should have been embraced by doctors. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. Discover special offers, top stories, Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: sorry about that. P-value was 10^-14 on that study (done by Dr. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. Always be self aware when using fluvoxamine. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. So take the lowest likely effect size * 60% success rate and you are looking at an expected 45% reduction in death which is clearly better than a 0% reduction. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. This drug can save your life but you have to ask for it! He wrote on his personal website that hed been advised that being associated with the drug would immediately trash my credibility.. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. Doctors who have used fluvoxamine in the US and other countries swear by it. How can we get fluvoxamine? . It was tested in. Still, in the moment, his question threw me, and I stuttered. We asked Steve to tone it down. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". Doctors who are most familiar with the drug would prescribe it to their patients. This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. That way you can start immediately. . Jan 17. Do they sell it anywhere? Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. Links to evidence about fluvoxamine including the public data repository. In September, he resigned as CEO and gave up his board seat. So you can address your OCD and if you get COVID, youll can up the dose. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. . I have all of these on hand and I load up on vitamin D3 every day. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. Zero. The evidence is solid. Added to FLCCC protocols and Fareed-Tyson protocol among others. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. See this. Dosage there is 30mg once a day. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Summary of key evidence. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. FDA official fluvoxamine rejection. Peter Meinke, another former board member, spent nearly three decades in drug discovery at Merck. Adverse reactions/side effects. Compulsive hand washing? As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. Government agencies are ignoring the science. The FDA approved Molnupiravir which was less effective. Since making a fortune as the founder of Infoseek, an early search engine that was the Google of its day, Kirsch has spent tens of millions of dollars fighting humanitys biggest threats. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. This is the gold standard of evidence based medicine. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. All have had a 100% success record in keeping their patients out of the hospital. All can merit a fluvoxamine prescription based on traditional diagnoses. . As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. They left their recommendation of fluvoxamine at NEUTRAL. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Proxalutamide and fluvoxamine pushers and the early treatment grift. Those days are gone. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. . Three of the four outpatient trials have been reported out: all were successful. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. Online Status. Drug interactions should be checked for. The NIH wrote a bullshit rejection because the FDA told them not to approve it. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Always be self aware when using fluvoxamine. How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? Their willingness to lie did. reach out to us at Some speaker, off camera, went on a . CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. All the medical journals refused to publish the meeting notes (rejected by 6 journals). Fluvoxamine has at least a 30% hospitalization and death benefit. skirsch.io Steve Kirsch Home page. While Fauci was crafting national pandemic policies, Fauci's wife [Christine Grady, Chief Bioethicist, NIH] was back stopping [them]." Report coming soon. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. Personal life. One of the drugs, Fluvoxamine, showed a 30 . Steven Todd Kirsch is an American entrepreneur. There were no studies reported out so far where fluvoxamine made things worse or neutral. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. Fluvoxamine, COVID, pandemic, . Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Stopping the meds will return you to your normal self. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? . It was so bad you couldnt even see the babys body through all the blood, Kirsch said. So far, doctors have failed to share his sense of urgency. I couldn't agree more. These people never called the researchers whose trials they claimed showed no effect. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead. My favorite dosage is 50mg twice a day for 14 days. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. Mouse Systems is not a household word, he told the journalist. But the whole process has gone too slowly for Kirsch. Substitutions. It will be months before enrollments are complete. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. That was a lie. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. Don't underestimate the virus. Design thinking was supposed to fix the world. MD, MPH; Steven C. Marcus, PhD. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. Reason is the hospital gets release from liability if they follow NIH guidelines. He retired at the largest pension in federal history. One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). This is why Cliff doesnt talk to me. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. Why not fluvoxamine? In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. We need to keep people out of the hospital in the first place. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. Medicine today isnt about saving your life. Food/drugs to avoid while on fluvoxamine. Three of the four outpatient trials have been reported out: all were successful. But a panel of key opinion leaders from the NIH, CDC . Most doctors wont use it until NIH greenlights it, no matter what the science says. Most recent articles first. Author Affiliations Article Information. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Ive used it personally at 50mg twice a day and experience no adverse events at all. Skirsch.io Steve Kirsch Home page Fluvoxamine, COVID, pandemic, . Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. For decades, coders wrote critical systems in C and C++. and increased heart rate (which could be nerves about the dilated pupils). The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. Share this post. You can use fluoxetine as well (aka Prozac). The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. In other cases, stop cold turkey. just like ivermectin). The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. Most recent articles first. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. Both drugs have compelling data that is hard to explain if the drug doesn't work. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. The 5 observational studies is icing on the cake. Saving the world has been a theme of Kirschs life for years. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. 533. But they dont want their names used. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. Avoid caffeine, benadryl, tylenol, and alcohol. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. Is that really true? Drug researchers at Washington University in St. Louis reached out to Kirsch looking for $67,000 to finish a very smallbut placebo-controlledtrial. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. Steve angrily decried this development as more evidence of FDA corruption. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Author Affiliations . . The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. The NIH wrote a bullshit rejection because the FDA told them not to approve it. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. I took it myself at that dosage and noticed zero side effects. If you cant lay off the java, then try fluoxetine (Prozac). Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Or just depression about the vaccine mandates? Items included in the Television News search service. The drug was FDA-approved more than 65 years ago. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. just like ivermectin). Telling the truth, he tweeted. Long haul. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness.
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